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The American Association for the Study of Liver Diseases (AASLD) and the British Society of Gastroenterology (BSG) recommend combination therapy, using the corticosteroid prednisone with azathioprine.
These drugs block the effect of angiotensin II, a chemical that narrows blood vessels.
Approximately one third of patients present with symptoms of acute hepatitis marked by fever, hepatic tenderness, and jaundice.
Some patients go on to develop signs and symptoms of chronic liver disease, while others rapidly progress to acute liver failure, as marked by coagulopathy and jaundice.
Reduced blood pressure makes it easier for the heart to pump blood and can improve heart failure.
In addition, the progression of kidney disease caused by the high blood pressure or diabetes is slowed.